The “Tiantan Symposium for Movement Disorders” was held on July 9, jointly organized by China Science Exchange Center, National Clinical Medical Research Center for Neurological Disorders, Beijing Titan Hospital, Capital Medical University, and Chinese Society of Gerontology and Geriatrics, and undertaken by the Center Brain Bank and Titan Brain Health Volunteer Group. Experts in the field of neuroscience, including Professor Martyn Goulding, winner of the Brain Prize 2022 (USA), and Professor Pu Muming, Chinese academician of brain science, elaborated on the basic science of movement disorders; Professor Irene Litvan from the University of California and Professor Piu Chan from Xuanwu Hospital, Capital Medical University, addressed clinical perspective of movement disorders. A total 10 overseas experts from Weden, Switzerland, Australia and Denmark participated in this symposium. In China, besides speakers from Beijing Tiantan Hospital, experts from other hospitals in Beijing, Sichuan, Guangzhou, Shanghai, Shenyang, etc. gave lectures and shared their unpublished research update. The symposium was jointly convened by Mr. Ning Li, China Science and Technology Exchange Center, Professor Yue Huang, China Central Brain Bank, and Prof. Irene Litvan, MDS faculty representative. The entire program was broadcasted in Chinese and English channels. There were over 700 registrations in the virtual symposium. The workshop was supported by the National Natural Science Foundation of China (NSFC. ID 82071417) and the International Parkinson and Movement Disorders Society (MDS) Continuing Education Program.
    
This symposium aims to discuss the unmet clinical needs of movement disorders and corresponding countermeasures on current hot topics of movement disorders. The conference is divided into three parts: Identifying Unmet Clinical Needs in Movement Disorder Disorders, Lunch Seminar-Huntington Session, and Solutions to Those Unmet Clinical Needs in Movement Disorders. It was an informative academic experience for a wide range of colleagues who are in the field of clinical neuroscience.
 
In the morning of July 9th, the special session on Identifying Unmet Clinical Needs in Movement Disorder Disorders:
 Part I was chaired by Wu Cheng, Deputy Director of the China Center for Science and Technology Exchange. Ms. Wu addressed the purpose of the symposium, the current status of brain science development and current efforts in China on brain science research; Prof. Muming Pu, member of the Chinese Academy of Sciences, foreign member of the US Academy of Sciences, and current academic director of the Chinese Academy of Sciences Center of Excellence in Brain Science and Intelligent Technology gave a presentation on neuroplasticity and its implications for movement disorder disorders; Professor Irene Litvan, Director of the Center for Parkinson's and Other Movement Disorders at the University of California, San Diego Health Center and representative of MDS gave a presentation on progressive supranuclear extraocular muscle palsy, an atypical Parkinson's syndrome.
Figure 1
The second part was chaired by Prof. Weidong Le, Director of Department of Neuroscience, Sichuan Provincial People's Hospital; Prof. Piu Chan, Director of Geriatric Department, Xuanwu Hospital, Director of National Clinical Medical Research Center for Geriatric Diseases and Director of Parkinson's Disease Institute, introduced the classification of different subtypes of Parkinson's disease; Prof. Wei Zhang, Director of Cognitive Disorders Department, presented the talk of The necessity of identifying specific non-motor symptoms of movement disorders.
  The third part was chaired by Prof. Qi Shi, Deputy Director of Prion Unit, Institute of Virus, Chinese Center for Disease Prevention and Control: Prof. Tao Xie from the University of Chicago Medical Center, USA, explained the current treatment options for atypical Parkinson's disease; Prof. Chao Peng, Assistant Professor of Neurology, University of California, Los Angeles, USA, introduced Conformational Diversity of Pathological Proteins: Input from the Intracellular Environment
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  The fourth session was chaired by Martin Meyer, President of the Brain Prize Jury, who introduced the Danish Lundbeck Foundation and the Brain Prize; Professor Martyn Goulding, Professor of Molecular Biology at the Salk Institute and recipient of the 2022 Brain Prize, gave a presentation on the need to understand how the brain-spinal motor system works.  
At noon on the 9th, a special session on Huntington's disease was chaired by Professor Jean Marc, Professor Emeritus of Experimental Neurology, Faculty of Medicine, University of Bern, Switzerland. Prof. Samuel Frank from BIMC department of Neurology, who is the Chair of American Academy of Neurology, Experimental Neurotherapeutics Section, gave a presentation of New Horizons in Treatment and Management of Huntington’s Disease. Prof. Huifang Shang introduced the clinical features and standardized treatment of Huntington's disease; Prof. Xinhua Wan, Chief Physician of the Department of Neurology, Peking Union Medical College Hospital, introduced a new class of VMAT-2 inhibitors for the treatment of Huntington's disease and late-onset movement disorders; Prof. Zhiying Wu, Chief Physician of the Second Hospital of Zhejiang University, introduced the phenotypic characteristics and factors affecting Huntington's disease patients in China.
   
In the afternoon of the 9th, a special session on solutions for unmet needs was held. The first part of the clinical assessment topic was moderated by Dr. Run-Qi Wangqin, Department of Neurology, Duke University Medical Center, USA: Dr. Zixuan Yang, Royal Atreides Hospital, Australia, introduced the non-motor symptoms of movement disorder diseases, the MDS scale with Chinese translation and the factors to be considered in applying the MDS scale; Prof. Jean Marc Burgunder, Medical School, the University of Bern, Switzerland, presented clinical experience with video-based movement disorder assessment.
   
The second part of the biomarker topic was chaired by Prof. Boyan Fang, chief physician of Beijing Rehabilitation Hospital affiliated to Capital Medical University: Prof. Zhong Pei, the First Hospital affiliated to Sun Yat-sen University introduced blood biomarkers of movement disorders; Prof. Tao Wu,  Beijing Tiantan Hospital, Capital Medical University gave a talk on neuroimaging characteristics of Parkinson's disease.
 
The third part of the topic of definitive diagnosis was chaired by Prof. Gang Wang, the Chief Physician of Shanghai Ruijin Hospital, Shanghai Jiao Tong University and Deputy Director of the Department of Neurology: Prof. Jiayi Li from China Medical University and formerly of the School of Life Sciences and Health, Lund University, Sweden, gave a lecture on the neuropathology of Parkinson's and the new pathogenesis of Parkinson's disease: the transmission of prion-like pathogenic proteins. Prof. Yue Huang, Director of the Brain Bank of the National Clinical Medical Research Center for Neurological Disorders of Beijing Tiantan Hospital, introduced neuropathological comparison of Parkinsonian disorders with Huntington's disease; Prof. Gang Wang and Prof. Jiayi Li also discussed whether Tau protein deposition in undemented normal elderly people also follows the rule of prion like protein transmission.
 
 
At the end, Prof. Yue Huang gave a summary, thanked all the experts and staffs behind the scenes for their support and assistance to this symposium. The invited speakers for this symposium originated from different continents with different time zooms. Their efforts made it successfully. This symposium strengthened the mutual communication and understanding between basic and clinical sciences, promoted the knowledge dissemination of the latest research progress on movement disorders. Through academic exchanges on movement disorders among peers, it contributed to the advancement of medical, educational, and scientific research on movement disorders. The bilingual live broadcast feature of this symposium provided valuable material and a model of international exchange for medical practitioners to be able to correctly understand the content expressed in English and to be in line with international standards.
 
Acknowledgments: 
It is very grateful to the experts who gave up their own free time to deliver their experiences on movement disorders. Some experts from the United States stayed up very late for their tasks and even stayed over midnight at their time zone. It is everyone's support that brings the symposium to a successful close.
Every expert gave a wonderful speech, fully elaborated on the unresolved clinical needs, the characteristics, diagnosis, neuropathological and other related issues on movement disorders, as well as the latest advances in the treatment and research, demonstrating their professionalism.
Finally, thanks to the support from MDS and other unnamed members. Hope the COVID-19 epidemic will end soon, so we can invite the experts to visit China. Looking forwards to meeting in person to have more interactions.